His artistic practice emerges from reflections on space and its various relationships with the human essence, using photography as his primary medium. Morales has exhibited both individually and collectively since 1995.

Among his most notable exhibitions are those held at  the Curitiba Biennial VentoSul, Brazil (2006); the Museum of Modern Art (MAMBO), Colombia (2016); Les Rencontres d’Arles, France (2024); the International Biennial BIAM Antioquia, Medellín (2025), Alonso Garces Bogota 2024, Aura Espacio Medellin 2021,  Nadar Gallery in Tokyo (2009)  among  others.

He has developed several solo projects exploring notions of space, including Tránsito (Universidad Nacional, Medellín, 2009), Prótesis (Sala de Arte Suramericana, 2009). 

He has also participated in international group shows such as Five Colombian Views in Japan, the XI Salon of Artists of the Central West Region, and the 40th National Salon of Artists Colombia.

Morales was the winner of the XI Colombo–Swiss Photography Prize, in 2015.

Luis Morales graduated as a Doctor from the University CES  in Colombia  and later specialized in surgery at the Hospital Barata Ribeiro in Rio de Janeiro, Brazil. He studied photography at the International Center of Photography (ICP) in New York. he has exhibited both individually and collectively since 1995.

His work is part of public and private collections.